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scientific articles

Subcutaneous Movable Spherules in the Ehlers-Danlos Syndrome

key information

source: Proceedings of the Royal Society of Medicine

year: 1938

authors: Weber FP, Aitken JK


This is the patient, Mrs. M. B., aged 34, whose case was described in the Lancet (1938 (i), 198), as a peculiar example of the Ehlers-Danlos syndrome, the remarkable feature of which is the presence of freely movable subcutaneous nodules or ” spherules especially in regions where the skin is loose (cutis laxa) ; the atrophic, ” papyraceous scars, which constitute the most important sign in most cases, are very few in the present patient. Over-extensibility of joints is best marked at the proximal interphalangeal articulations. There are no gross abnormalities apart from those of the Ehlers-Danlos syndrome.

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