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scientific articles

Osteoporosis and Ehlers-Danlos Syndrome

key information

source: Annals of the Rheumatic Diseases

year: 1994

authors: Coelho PC, Santos RA, Gomes JA

summary/abstract:

The changes in bone mineral content of patients with Ehlers-Danlos syndrome (EDS) are still not wholly defined. Although well described in diseases of the same group (osteogenesis imperfecta, homocystinuria), osteoporosis is seldom consistently referred to in association with EDS. Prockop suggests that the mutations altering the sequence of the N-terminal extremity of the procollagen, as is the case with some groups of EDS, would not cause a diminution of the bone mass. However, some studies appear to indicate that in EDS there is an alteration in the normal bone metabolism, finding an increase in the frequency of vertebral fractures and ultrastructural changes in the collagen fibrils. It also seems that there is a lower absorption of tetracycline in the bone tissue of patients with type I EDS.

organization: Hospital Militar Principal Lisbon

DOI: 10.1136/ard.53.3.212-b

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