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scientific articles

Joint Hypermobility Syndrome and Postural Orthostatic Tachycardia Syndrome (HyPOTS)

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source: Biomedical Research and Clinical Practice

year: 2017

authors: Dana Mandel, Ali D. Askari, Charles J. Malemud, Artan Kaso


Objective: To evaluate the association between joint hypermobility syndrome associated with postural orthostatic tachycardia syndrome (HyPOTS) and fibromyalgia.

Methods: A chart review of patients followed at two outpatient Rheumatology facilities within one hospital system were analyzed.  Thirty-seven patients (3 male, 34 female) diagnosed with HyPOTS and fibromyalgia were reviewed.

Results: HyPOTS is a chronically disabling musculoskeletal disorder presenting clinically as widespread musculoskeletal pain and/or fatigue with joint hypermobility. However, HyPOTS may be inadvertently diagnosed as chronic fatigue syndrome or fibromyalgia. In fact, the group of fibromyalgia patients evaluated at a rheumatology outpatient clinic were found to meet the clinical criteria for HyPOTS.

Conclusions: Patients diagnosed with fibromyalgia and chronic fatigue syndrome may benefit from a further evaluation for HyPOTS. Thus, if HyPOTS is properly defined, a wide range of therapeutic options for these patients become available in order to improve their physical manifestations and quality of life.

organization: University Hospitals Cleveland Medical Center

DOI: DOI: 10.15761/BRCP.1000132

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