welcome to oneEDSvoice

- a positively charged Ehlers Danlos Syndrome community.
  • join today!
scientific articles

Fatigue is a Frequent and Clinically Relevant Problem in Ehlers-Danlos Syndrome

key information

source: Seminars in Arthritis and Rheumatism

year: 2010

authors: Voermans NC, Knoop H, van de Kamp N, Hamel BC, Bleijenberg G, van Engelen BG

summary/abstract:

OBJECTIVES:
Ehlers-Danlos Syndrome (EDS) is a clinically and genetically heterogeneous group of inherited connective tissue disorders characterized by joint hypermobility, skin hyperextensibility, and tissue fragility. Fatigue and musculoskeletal pain are associated features but have never been studied systematically. We used a multidimensional assessment method to measure fatigue, its clinical relevance, and possible determinants.
METHODS:
A questionnaire study was performed among 273 EDS patients. The following dimensions were assessed: fatigue severity, functional impairment in daily life, physical activity, psychological distress, sleep disturbances, concentration problems, social functioning, self-efficacy concerning fatigue, causal attribution of fatigue, pain, and disease-related factors.
RESULTS:
More than three-quarters of EDS patients suffer from severe fatigue. Patients who are severely fatigued are more impaired than nonseverely fatigued patients and report a higher level of psychological distress. The 5 possible determinants involved in fatigue are sleep disturbances, concentration problems, social functioning, self-efficacy concerning fatigue, and pain severity.
CONCLUSIONS:
This is the first study of fatigue and its possible determinants in EDS and shows that fatigue is a frequent and clinically significant problem in EDS. The 5 possible determinants of fatigue could form a starting point for the development of an effective cognitive behavioral intervention for fatigue in EDS.

organization: Neuromuscular Centre Nijmegen

DOI: 10.1016/j.semarthrit.2009.08.003

read more full text source

expertly curated content related to this topic