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Ehlers Danlos Syndrome and Osteoporosis
source: Annals of the Rheumatic Diseases
year: 1994
authors: Deodhar AA, Woolf AD
summary/abstract:Ehlers Danlos syndrome (EDS) is a group of inherited connective tissue disorders with extreme genetic and clinical variability.’ The clinical manifestations of EDS are a result of abnormalities in collagen types 1 and 3, the major proteins of skin, ligaments, tendons, blood vessels, and internal viscera. Type 1 collagen is also the main protein constituent of the bone matrix and its abnormalities form the molecular basis of osteogenesis imperfecta (OI). EDS is therefore quite closely linked to OI and the two conditions are known to coexist. In spite of this there are no detailed studies available on bone mineral content in patients with EDS. In the past three years we have seen seven patients with EDS and assessed bone densities in the lumbar spine and hip using dual energy x ray absorptiometry.
organisation: Royal Cornwall HospitalDOI: 10.1136/ard.53.12.841-c
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