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completed

IGF-I Stimulation of Collagen Synthesis in Ehlers-Danlos Patients

key information

study id #: NCT01446783

condition: Ehlers-Danlos Syndrome, Classic

status: completed

purpose:

The investigators want to inject insulin-like growth factor-I (IGF-I) into the patella tendon of Ehlers-Danlos patients and healthy controls to evaluate the response in collagen synthesis. Furthermore collagen synthesis is measured in muscle connective tissue and in skin. The hypothesis is that the connective tissue in Ehlers-Danlos patients is more compliant and poorer in collagen than healthy controls, but that collagen synthesis can be stimulated by IGF-I.

intervention: Drug: mecasermin
0,1 ml mecasermin (10 mg/ml) is injected intratendinous into the patella tendon with ultrasound guidance.
Other Name: Increlex (mecasermin), Ipsen
Drug: Saline
0,1 ml saline is injected intratendinous into the patella tendon with ultrasound guidance.