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Clinical Autonomic Disorders: A Training Protocol

key information

study id #: NCT02154009

condition: Chronic Fatigue Syndrome, Pseudopheochromocytoma, Healthy Volunteers, Neurocardiogenic Syncope, Postural Tachycardia Syndrome

status: completed


Background: – The autonomic nervous system helps control things that happen automatically in the body, like blood pressure, heart rate, and digestion. When it doesn t work properly, it s called dysautonomia. Researchers want to learn more about dysautonomias and train doctors to learn how to better diagnose them.


  • To allow people with autonomic disorders to be evaluated.
  • To help fellows in the NIH Autonomic Disorders fellowship program see a variety of diseases in their training.


  • People age 18 and older with dysautonomia; children over age 2 if they might benefit
  • Healthy adult volunteers


  • Participants will have different procedures depending on their symptoms. They will have one or more visits. They will have some but not all of the tests below.
  • Participants will have a medical history and physical exam. They may be tested for problems thinking. They may complete a symptom questionnaire. They may have their temperature and blood pressure taken.
  • Participants may have an intravenous line placed. A needle will guide a thin plastic tube into an arm vein.
  • Participants may have blood drawn several times. They may give a urine sample.
  • Participants may have an electrocardiogram.
  • How much blood a participant s heart is pumping and/or how much blood is flowing through their arm may be measured. The total amount of blood in their bloodstream may be measured.
  • Participants may have their ability to sweat and/or sense of smell tested.
  • Breathing, bowel sounds, and/or body functions may be monitored.
  • Pupil size, response to environmental temperature changes, and/or breathing may be measured.
  • Participants may have a bladder ultrasound.
  • Small pieces of skin may be taken for study.